MRT-68921 hydrochloride ( MRT 68921 hydrochloride;MRT68921 hydrochloride )

产品货号. M13240 CAS No. 2080306-21-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MRT-68921 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
产品描述

MRT-68921 hydrochloride (MRT68921) is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
同义词

MRT 68921 hydrochloride;MRT68921 hydrochloride
通路

Autophagy
靶点

ULK
受体

ULK
研究领域

——
适应症

——

CAS Number

2080306-21-2
分子量

471.04
分子式

C25H35ClN6O
纯度

>98% (HPLC)
溶解度

H2O: 10 mg/mL
SMILES

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5.Cl.Cl
化学全称

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-,hydrochloride (1:2)

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

计算器

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关联产品

LYN-1604

LYN-1604 is a potential ULK1 agonist (enzymatic activity=195.7% at 100 nM and IC50=1.66 uM against MDA-MB-231 cells).
MRT-68921

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
MRT67307

MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.